Concepedia

Optimal Oral Anticoagulant Therapy in Patients with Mechanical Heart Valves

Suzanne C. Cannegieter, Frits R. Rosendaal, Axel R. Wintzen, F.J.M. van der Meer, Jan P. Vandenbroucke, E Briët

New England Journal of Medicine · 1995 · 910 citations · 19 references

DOIFull text

Open access

Abstract

The intensity of anticoagulant therapy for patients with prosthetic heart valves is optimal when the INR is between 2.5 and 4.9. To achieve this level of anticoagulation, a target INR of 3.0 to 4.0 is recommended.

References

19

A Method to Determine the Optimal Intensity of Oral Anticoagulant Therapy

F.R. Rosendaal, Suzanne C. Cannegieter, F.J.M. van der Meer et al. · Thrombosis and Haemostasis · 1993 · 2K citations

, , +19

Risk Factors for Intracranial Hemorrhage in Outpatients Taking Warfarin

Elaine M. Hylek · Annals of Internal Medicine · 1994 · 920 citations

Risk Factors for Complications of Chronic Anticoagulation: A Multicenter Study

Stephan D. Fihn · Annals of Internal Medicine · 1993 · 671 citations

A Comparison of Aspirin with Placebo in Patients Treated with Warfarin after Heart-Valve Replacement

Alexander G. G. Turpie, Michael Gent, Andreas Laupacis et al. · New England Journal of Medicine · 1993 · 549 citations · Full text

Bleeding complications in oral anticoagulant therapy. An analysis of risk factors

F J van der Meer · Archives of Internal Medicine · 1993 · 542 citations