Organic Letters · 2008 · 18 citations · 20 references
Life SciencesBiomolecular EngineeringMolecular BiologyBioorthogonal ChemistryBiophysical ChemistryMolecular BiotechnologyDna ChemistryDna LigationDna StructureOligonucleotide ChemistryChemical Modification Of OligonucleotidesPhotocleavage Of Nucleic Acids
We describe a light-controlled template-directed reversible DNA photoligation via carbazole-tethered 5-carboxyvinyluracil. Carbazole-tethered 5-carboxyvinyl-2'-deoxyuridine-containing oligodeoxynucleotide (ODN) can be ligated by irradiation at 366 nm in the presence of template ODN, and the ligated ODN can be split by irradiation at 366 nm in the absence of template ODN.
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Ravindra Kumar, Afaf H. El‐Sagheer, John Tumpane et al. · Journal of the American Chemical Society · 2007 · 268 citations