Concepedia

Safety, efficacy and weight effect of two 11β‐ <scp>HSD1</scp> inhibitors in metformin‐treated patients with type 2 diabetes

Tim Heise, Linda Morrow, Marcus Hompesch, Hans‐Ulrich Häring, Christoph Kapitza, Maryline Abt, Markus Ramsauer, Maria Chiara Magnone, Sabine Fuerst‐Recktenwald

Diabetes Obesity and Metabolism · 2014 · 43 citations · 15 references

DOI

Abstract

Slight metabolic improvements were seen, in particular with RO-151 high dose, however, the observed changes often did not reach statistical significance and were not clearly dose dependent. Studies of longer duration are needed to further investigate potential benefits and risks of these compounds.

References

15

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David R. Matthews, J P Hosker, A. Rudenski et al. · Diabetologia · 1985 · 31K citations · Full text

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Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

Masafumi Matsuda, Ralph A. DeFronzo · Diabetes Care · 1999 · 5.5K citations

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

Hiroaki Masuzaki, J. Paterson, Hiroshi Shinyama et al. · Science · 2001 · 1.8K citations

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Improved Lipid and Lipoprotein Profile, Hepatic Insulin Sensitivity, and Glucose Tolerance in 11β-Hydroxysteroid Dehydrogenase Type 1 Null Mice

Nicholas M. Morton, Megan C. Holmes, Catherine Fiévet et al. · Journal of Biological Chemistry · 2001 · 435 citations · Full text

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice

Hiroaki Masuzaki, Hiroshi Yamamoto, Christopher J. Kenyon et al. · Journal of Clinical Investigation · 2003 · 426 citations · Full text

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