Dermatology · 2009 · 10 citations · 0 references
MedicineDermatologyPathologyDermatopathologyHistopathologyImmunopathologyAutoantibodiesAutoantigensAutoimmune DiseasesAutoimmune Skin DiseasesImmunoglobulin DisordersImmunopathology Of SkinAcantholytic DisordersAnti-desmoglein AutoantibodiesAutoantibodies In Skin DiseaseAutoimmune Blistering DermatosesDesmoglein AutoantibodiesImmunofluorescence FindingsImmunofluorescence StainingVesiculobullous Dermatoses
A case is reported of a 60-year-old woman with acantholytic vesiculopustular dermatosis and IgA-lambda monoclonal gammopathy. The histopathology of vesiculopustular lesions showed intraepidermal acantholytic and neutrophilic blisters. Direct immunofluorescence revealed intercellular (IC) IgD deposition with concurrent deposits of IgA and C3. Indirect immunofluorescence and immunoblotting studies revealed that the patient had circulating IgG and IgA anti-IC antibodies both of which recognized the 150-kD desmoglein that was pemphigus foliaceus antigen in a bovine desmosome preparation.