Relation between serum Insulin‐like growth factor‐I and insulin‐like growth factor‐binding protein‐3 levels, clinical status and growth parameters in prepubertal cystic fibrosis patients

Abstract

Decreased serum IGF-I and IGFBP-3 levels may reflect growth retardation in CF. IGFBP-3 seems like a more sensitive parameter than IGF-I for growth monitoring in this study. Growth parameters of Turkish prepubertal CF patients are not markedly below national standards. Different genetic backgrounds of relevant populations certainly play an important role for the variable clinical course.