Journal of Occupational and Environmental Medicine · 2009 · 30 citations · 40 references
PharmacyEnvironmental SciencesToxicologyAir PollutionEnvironmental HealthEnvironmental ToxicologyAir Pollution EpidemiologyBiomarkers Of Genotoxic ExposureDna DamageExposure AssessmentOxidative Damage To BiomoleculesOxidative StressAntihypertensive TreatmentFine Particulate MatterFine Particulate Matter Health EffectsOxidative Damage BiomarkersOxidative Dna DamageOxidative Stress BiomarkersPanel Study DesignPm2.5
OBJECTIVE: To investigate the association between particulate matter (PM2.5) and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in hypertensive and non-hypertensive individuals. METHODS: Twelve hypertensives and nine non-hypertensives were monitored during a 36-hour period using a repeated-measures panel study design. Personal exposure to PM2.5 was assessed using a real-time continuous monitor. Spot urine samples collected at 12-hour intervals were analyzed for 8-OHdG. RESULTS: Exposure to PM2.5 was associated with a decrease in 8-OHdG in hypertensives compared with an increase in non-hypertensives, after adjusting for age, gender, smoking status, and time of day. CONCLUSIONS: The results suggest modification of the association between PM2.5 exposure and urinary 8-OHdG by hypertension status. Antioxidant activity present in antihypertensive medications may play a role or PM2.5 exposure may reduce the capacity to repair DNA damage in hypertensives. These results should be confirmed with further investigation.
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Epidemiology Standardization Project (American Thoracic Society).