CYTOKINETIC AND CYTOGENETIC CHANGES IN CULTURED HUMAN LEUCOCYTES AND HELA CELLS INDUCED BY BENZENE

Abstract

Action of benzene on human leucocytes and on HeLa cells were examined from cytokinetic and cytogenetic points of view. Dose-response type analysis revealed that decreased DNA synthesis of cultured human leucocytes and of HeLa cells were re-markable in dose level of 2.2×10-3 M of benzene. As far as chromosome aberrations of cultured human leucocytes were concerned, gaps and breaks were observed in dose levels of both 2.2×10-3 M and 1.1×10-3 M of benzene.