Further Insights into the Underlying Electrophysiological Mechanisms for Reduction of Atrial Fibrillation by Ranolazine in an Experimental Model of Chronic Heart Failure

Abstract

RAN has been shown to be effective in reducing the inducibility of AF in an experimental model of AF. The antiarrhythmic effect is mainly due to development of atrial post-repolarization refractoriness and a moderate increase in conduction time. The described electrophysiological mechanisms remain preserved in the setting of CHF.