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Enzymatic differentiation of the enantiotopic hydroxymethyl groups of glycerol; synthesis of chiral building blocks
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1986
Year
BiosynthesisBioorganic ChemistryEngineeringBiochemistryChiral Building BlocksNatural SciencesMolecular BiologyEnzymatic DifferentiationEnantiotopic Hydroxymethyl GroupsOrganic ChemistryGlycerol SkeletonStereoselective SynthesisEnzymatic HydrolysisEnzymatic ModificationNatural Product SynthesisAsymmetric CatalysisEnantioselective SynthesisBiomolecular Engineering
The prochiral (3b), derived from glycerol, was transformed by enantioselective, enzymatic hydrolysis into the central chiral building block (R)-(4) of high enantiomeric purity, which was further elaborated into a variety of chiral building blocks with the glycerol skeleton.