Enantioselective organocatalytic reductive amination of aliphatic ketones by benzothiazoline as hydrogen donor

Abstract

The chiral phosphoric acid-catalyzed enantioselective reductive amination of aliphatic ketones with aromatic amines was successfully achieved by the use of benzothiazoline as the hydrogen donor. Corresponding chiral aliphatic amines were obtained with excellent enantioselectivities.