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Mechanisms of Oral Staphylococcal Enterotoxin B-Induced Emesis in the Monkey
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1975
Year
ImmunologyGastroenterologySed-induced VomitionDigestive TractFunctional Gastrointestinal DisorderGut-organ AxisInfection ControlSensationHealth SciencesMicrobial ToxinNervous SystemClinical MicrobiologyOral Seb ChallengeNeurophysiologyNeuroanatomyPathogenesisPhysiologyEnterotoxin AbsorptionNeuroscienceGut BarrierCentral Nervous SystemMedicine
Vomition is the most consistent response to oral SEB challenge in the monkey. The technique of cross-circulation clearly differentiates local neural phenomenon from humoral mechanisms. Our results support the theory that SED-induced vomition follows stimulation of local neural receptors in the gut. The evidence indicates no significant amount of enterotoxin absorption or stimulation of vomition by any centrally acting humoral mechanism.