The Bone Fracture–Healing Potential of<i>Ormocarpum cochinchinense</i>, Methanolic Extract on Albino Wistar Rats

Abstract

Ormocarpum cochinchinense has been traditionally used for curing bone fracture in the villages of Tamil Nadu, India. Significant healing of bone fractures was observed in experiments with the albino Wistar rats. Animals treated orally as well as topically showed healing effects within 7 days by radiological examination and those treated topically alone had lower healing effects. Biochemical analysis of minerals and enzymes associated with bone healing showed a positive trend with serum Ca, inorganic phosphorus, and alkaline phosphatase concentrations in animals treated orally and topically. The concentration of Ca was reduced on the seventh day and increased on the fourteenth and twenty-first days.