Streptomycin Therapy in 52 Cases of Bacterial Infection

Abstract

STREPTOMYCIN, an antibiotic agent obtained from certain strains of Actinomyces griseus, was first described by Schatz, Bugie and Waksman1 in 1944. Immediate interest was attracted to this agent because of its effectiveness in vitro against bacteria that had previously been resistant to the action of known antibiotic and chemotherapeutic agents. Animal studies have demonstrated that the toxicity of streptomycin is of a relatively low order,2 and the results in the treatment of experimental infections have proved its effectiveness in vivo.2 3 4 5 Clinical trials in the past two years have confirmed its low toxicity and demonstrated its value in the treatment . . .