4-Chloro-m-cresol is a Trigger of Malignant Hyperthermia in Susceptible Swine

Abstract

4-CmC is in vivo a trigger of malignant hyperthermia in swine. However, the 4-CmC doses required for induction of malignant hyperthermia were between 12 and 24 mg/kg, which is about 150-fold higher than the 4-CmC concentrations within clinically used preparations.