The Oxygen‐Mediated Synthesis of 1,3‐Butadiynes in Continuous Flow: Using Teflon AF‐2400 to Effect Gas/Liquid Contact

Abstract

The gas is always greener: A continuous flow Glaser–Hay coupling reaction system, mediated by molecular oxygen, is developed based on a tube-in-tube gas/liquid reactor/injector. The system uses a semi-permeable Teflon AF-2400 membrane to effect rapid gas/liquid contact in flow, affording homogeneous solutions of oxygen. Measurements of out-gassing downstream of the back-pressure regulator indicate the onset of saturation is reached after about 16 seconds.