Archives of Neurology And Psychiatry · 1953 · 83 citations · 39 references
Parathyroid DiseaseCentral Neurological ComplicationsPeripheral NervePeripheral NervesPeripheral Nervous SystemSocial SciencesHyperpolarization (Biology)NeurologyNeuropathologyProgressive Supranuclear PalsyCalcium IonsNervous SystemNeuromuscular PhysiologyNerve FibersNeurological SurgeryLow Calcium IonsNeurophysiologyPhysiologyNeuroscienceElectrophysiologyMedicineEndocrine Disease
IT IS WELL known that calcium ions are necessary for the proper functioning of nerve tissue. Lack of calcium ion increases the excitability of nerve tissue to the point that, in vitro, mammalian A fibers will discharge spontaneously in the presence of low calcium (Kugelberg,11944). Arvanitaki2(1942) was able to create an artificial synapse (ephapse) by allowing nerve fibers to cross one another: In the presence of low calcium ions, impulses set up in the receiving fiber were able to initiate propagated responses. The increased neuromuscular irritability in mammals associated with hypocalcemia is commonly termed tetany and is looked for in terms of carpopedal spasm, laryngeal stridor, muscular cramps, Chvostek's sign, and changes in electrical excitability of the peripheral nerves. Koenig and associates3(1952) have shown by nerve section and use of curare that all the phenomena of tetany can be ascribed to iterative discharges in
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Lorente de No R · PubMed · 1947 · 547 citations
Nerve Physiology, Peripheral Nerve Injury, Neurophysiology +9
The Parathyroid Glands and Metabolic Bone Disease: Selected Studies
JAMA · 1949 · 513 citations