Publication | Closed Access
Aflatoxin B <sub>1</sub> : Binding to DNA in vitro and Alteration of RNA Metabolism in vivo
185
Citations
9
References
1966
Year
Molecular BiologyCell DeathNucleic Acid BiomarkersToxicological MechanismOxidative StressTranscriptional RegulationNucleic Acid ChemistryMycotoxin FormationToxicologyRna ProcessingRna MetabolismBiochemistryRna BiologyDenatured DnaRna TransportExperimental ToxicologyGene ExpressionEquilibrium DialysisNatural SciencesNucleic Acid BiochemistryAflatoxin BMedicine
Aflatoxin B(1) binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B(1) may be direct results of the affinity of this agent for DNA.
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