Surgical OncologyCancer PharmacologyPathologyPharmacotherapyMetronomic ChemotherapyCancer ChemotherapyTumor BiologyMedicinal ChemistryOncologyBiological ScreeningAnti-cancer AgentHematopoietic PharmacologyRadiation OncologyChemotherapyCancer ResearchMolecular OncologySeptember 1961Clinically Available DrugsCancer TreatmentPharmacologyMedicineDrug Discovery
The chemotherapy of cancer, alongside surgery and radiotherapy, emerged in the 1940s and was critically reviewed by the WHO Expert Committee in 1961, covering experimental and clinical studies and noting developments in administration methods. The paper discusses all these new developments. The study reviews drug design, mechanism of action, biological screening, clinical trials, and the clinically available drugs and their indicated neoplasms. Since the 1961 report, many new compounds have been tested and some entered clinical trials.
The chemotherapy of cancer, in relation to surgery and radiotherapy, is a new method of attack. Its development, which started virtually in the 1940's, was reviewed by the WHO Expert Committee on Chemotherapy of Cancer that met in September 1961. The report of the Committee dealt with experimental and clinical studies in this field critically, but also to a necessary degree, comprehensively. The design and mechanism of action of the drugs, their biological screening and subsequent clinical trials were discussed, and a review was presented of the clinically available drugs and the neoplasms for which they were indicated. In the two years that have elapsed since the report was drawn up many new compounds have been tested and some have had clinical trials. There have been developments, too, in methods of administration. All these new developments are discussed in the present paper.
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Five Years Clinical Experience with 5-Fluorouracil
Fred J. Ansfield · JAMA · 1962 · 218 citations
Methylhydrazine derivatives, a new class of cytotoxic agents
P. Zeller, Heike Gutmann, B. Hegedüs et al. · Cellular and Molecular Life Sciences · 1963 · 93 citations · Full text