Quinazolincs. X. Direct formation of aminoquinazolines from hydroxyquinazolines and phenyl phosphorodiamidate

Abstract

Abstract Treatment of several types of liydroxyquinazoline ring systems with phenyl phosphorodiamidate resulted in direct formation of the corresponding aminoquinazolines. The reaction can be conducted either by fusion in the absence of solvent or with diphenyl ether added as a diluent. The main advantage of the method is that it obviates the usual requirement for chlori‐nation or thiation prior to animation.