Bioactive peptides derived from food proteins preventing lifestyle‐related diseases

TLDR

Bioactive peptides that can prevent lifestyle‑related diseases are released from food proteins during enzymatic digestion, including ACE‑inhibitory peptides with antihypertensive effects. Several isolated food‑derived peptides showed therapeutic effects, including LKPNM’s ACE‑activation and sustained antihypertensive action, ovokinin peptides’ oral antihypertensive activity, low‑molecular‑weight peptides’ cholesterol‑lowering without increased excretion, and a soybean‑protein peptide that prevented chemotherapy‑induced alopecia.

Abstract

Abstract Many kinds of bioactive peptides which might prevent lifestyle‐related diseases are released from food proteins after enzymatic digestion. Inhibitory peptides for angiotensin I‐converting enzyme (ACE) having anti‐hypertensive effect have been isolated from enzymatic digests of various food proteins. LKPNM, which was isolated from the thermolysin digest of dried bonito was activated 8‐fold by ACE itself and showed a prolonged effect after oral administration. Two vasorelaxing peptides, ovokinin and ovokinin(2–7), showing antihypertensive effect after oral administration were obtained from ovalbumin digests. We found that low molecular weight peptides derived from food proteins lowered serum cholesterol without increasing excretion of cholesterol and bile acids. An immunostimulating peptide isolated from an enzymatic digest of soybean protein prevented alopecia induced by cancer chemotherapy.