Publication | Open Access

Design and synthesis of 5-[(2-chloro-6-fluorophenyl)acetylamino]-3-(4-fluorophenyl)-4-(4-pyrimidinyl)isoxazole (AKP-001), a novel inhibitor of p38 MAP kinase with reduced side effects based on the antedrug concept

Medicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryP38 Map KinaseBiochemistryMedicineNatural SciencesAntedrug ConceptMechanism Of ActionPharmacological AgentPharmacotherapyAnti-cancer AgentDrug DevelopmentPharmacologyReduced Side EffectsDrug DiscoveryDrug Resistance