Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

On the Origin of Cancer Cells

Otto Warbürg · Science · 1956 · 13.3K citations

Medicine, Cancer Biology, Cell Biology +12

Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

Ralph J. DeBerardinis, Anthony Mancuso, Evgueni Daikhin et al. · Proceedings of the National Academy of Sciences · 2007 · 2.6K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Production of large amounts of hydrogen peroxide by human tumor cells.

Ted P. Szatrowski, Carl Nathan · PubMed · 1991 · 2.5K citations

Life Sciences, Biochemistry, Oncology +17

Cancer Cell Metabolism: Warburg and Beyond

Peggy P. Hsu, David M. Sabatini · Cell · 2008 · 2.5K citations · Full text

Life Sciences, Cancer Biology, Cell Biology +12

Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

Larry Reitzer, Burton M. Wice, David Kennell · Journal of Biological Chemistry · 1979 · 1.2K citations · Full text

Life Sciences, Biochemistry, Cell Biology +10