Concepedia

Oncostatin M–induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT‐1 and STAT‐3 signaling: An implication for the pathogenesis of arthritis

Sang‐Heng Kok, Chi‐Yuan Hong, Mark Yen‐Ping Kuo, Chih‐Chiang Wang, Kuo‐Liang Hou, Yi‐Ting Lin, Deborah L. Galson, Sze‐Kwan Lin

Arthritis & Rheumatism · 2009 · 39 citations · 38 references

DOI

Abstract

These findings show that multiple levels of STAT-1/3 signaling modulate OSM-stimulated CCL2 expression in human osteoblastic cells. Clinically, this pathway may be related to the pathogenesis of arthritis.

References

38

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

Zilong Wen, Zhong Zhong, James Darnell · Cell · 1995 · 2K citations · Full text

, , +12

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

Neil Stahl, Teri G. Boulton, Thomas J. Farruggella et al. · Science · 1994 · 976 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

Naftaly Meydan, T Grunberger, Harjit Dadi et al. · Nature · 1996 · 910 citations

, , +4

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

Jongkyeong Chung, Eriko Uchida, Timothy C. Grammer et al. · Molecular and Cellular Biology · 1997 · 617 citations · Full text

, , +15

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

B.J. Wagner, Timothy E. Hayes, Christine Hoban et al. · The EMBO Journal · 1990 · 607 citations · Full text

, , +11