Construction of 3D, Layered Skin, Microsized Tissues by Using Cell Beads for Cellular Function Analysis

Abstract

Microsized skin cell beads consisting of 3D layered structures with epidermal and dermal cells have been fabricated. The beads are monodisperse, type-I collagen beads encapsulating dermal cells and covered by epidermal cells. The beads can be used in individual analyses of cellular functions and respond to chemical stimulation.