Synthesis and evaluation of α,β-unsaturated α-aryl-substituted fosmidomycin analogues as DXR inhibitors

Fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis

Tomohisa Kuzuyama, Tomohiro Shimizu, Shunji Takahashi et al. · Tetrahedron Letters · 1998 · 378 citations

Specific Inhibitor, Biosynthesis, Biochemistry +8

Inhibition of the Non-Mevalonate 1-Deoxy-ᴅ-xylulose-5-phosphate Pathway of Plant Isoprenoid Biosynthesis by Fosmidomycin

Johannes Zeidler, Jörg Schwender, Christian Müller et al. · Zeitschrift für Naturforschung C · 1998 · 181 citations · Full text

Plant Physiology, Engineering, Secondary Metabolite +17

Direct formation of 2-C-methyl-d-erythritol 4-phosphate from 1-deoxy-d-xylulose 5-phosphate by 1-deoxy-d-xylulose 5-phosphate reductoisomerase, a new enzyme in the non-mevalonate pathway to isopentenyl diphosphate

Tomohisa Kuzuyama, Shunji Takahashi, Hiroyuki Watanabe et al. · Tetrahedron Letters · 1998 · 147 citations

Direct Formation, Biosynthesis, Engineering +10

Fosmidomycin plus Clindamycin for Treatment of Pediatric Patients Aged 1 to 14 Years with <i>Plasmodium falciparum</i> Malaria

Steffen Borrmann, Ingrid Lundgren, Sunny Oyakhirome et al. · Antimicrobial Agents and Chemotherapy · 2006 · 109 citations · Full text

Antibiotics, Antiparasitic Agent, Randomized Trial Designs +11

Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase

Lionel Kuntz, Denis Tritsch, Catherine Grosdemange‐Billiard et al. · Biochemical Journal · 2005 · 108 citations · Full text

Bioorganic Chemistry, Antiparasitic Agent, Escherichia Coli +18