International Archives of Allergy and Applied Immunology · 2009 · 16 citations · 0 references
MedicineGeneticsPharmacologyExperimental PharmacologyNeuropharmacologyPharmacodynamicsHypersensitivity PharmacologyRodent PharmacologySerotonergic PharmacologySerotonergic SignalingHistamine ReceptorsInbred Strain GeneticsPharmacology Of Serotonergic AgentsSerotonergic System EffectsSerotonin Pharmacodynamics
A large panel of inbred strains of mice and some of their Fl hybrids were tested on their sensitivity to the hemoconcentrating effects of intravenous injections of histamine alone, serotonin alone, or histamine-serotonin mixtures. Major differences in susceptibility were observed. Crosses and backcrosses were made between susceptible (SJL/J) and less susceptible (RF/J, C57BL/6J) strains; it was found that the sensitivity to vasoactive amines is, at least partially, inheritable.