Canadian Journal of Chemistry · 1978 · 36 citations · 1 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistryStructural BiochemistryStructural BiologyConformational AnalysisConformational ChangeCarbon-13 Nuclear Magnetic ResonanceChemical Shift AnalysisConfiguration Determination By Nuclear Magnetic Resonance SpectroscopyDihedral AngleDihedral EffectMolecular Conformation AnalysisNuclear Magnetic Resonance Conformational AnalysisNuclear Magnetic Resonance Structure Determination
The carbon-13 chemical shifts for a number of relatively rigid ketoximes are presented. It is shown that the chemical shift difference, Δδ (syn—anti), for the carbons α to the oxime carbon depends on the dihedral angle between the C=N and C α —H bonds. This stereochemical dependence is then used to determine the preferred conformation of substituted cyclohexanone oximes.
1