Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3β

A molecular mechanism for the effect of lithium on development.

Peter S. Klein, Douglas A. Melton · Proceedings of the National Academy of Sciences · 1996 · 2.3K citations

Xenopus Embryos, Engineering, Genetics +17

Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase.

Noor Embi, Dennis B. Rylatt, Philip Cohen · PubMed · 1980 · 915 citations

Muscle Function, Cellular Physiology, Muscle Physiology +21

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

José J. Lucas · The EMBO Journal · 2001 · 893 citations · Full text

Knockout Mouse, Neurodegenerative Diseases, Developmental Biology +9

Glycogen Synthase Kinase‐3 from Rabbit Skeletal Muscle

Philip Cohen · European Journal of Biochemistry · 1980 · 765 citations · Full text

Muscle Function, Enzymatic Modification, Cellular Physiology +16

Structure of GSK3beta reveals a primed phosphorylation mechanism.

Ernst ter Haar, Joyce T. Coll, Douglas A. Austen et al. · Nature Structural Biology · 2001 · 381 citations

Signal Transduction, Signaling Pathway, Primed Phosphorylation Mechanism +6