Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 5. 9-Deazahypoxanthines

Abstract

The synthesis and evaluation as inhibitors of purine nucleoside phosphorylase of six 9-deazahypoxanthines (2a-f) are reported. In contrast to reports in the literature of other hypoxanthine-guanine analog pairs, these inhibitors (2a-f) are equipotent with the corresponding 9-deazaguanines.