Renin-Angiotensin-Aldosterone System and Hypothalamic-Pituitary-Adrenal Axis in Hospitalized Newborn Foals

Abstract

RAAS activation in critically ill foals is characterized by increased ANG-II and aldosterone concentrations. Inappropriately low cortisol and aldosterone concentrations defined as high ACTH/cortisol and ACTH/aldosterone ratios in septic foals suggest that RAI is not restricted to the zona fasciculata in critically ill newborn foals.