Trypsin promotes efficient influenza vaccine production in MDCK cells by interfering with the antiviral host response

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Essential Function, Viral Replication, Molecular Virology +10

Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems

Adolfo Garcı́a-Sastre, Andrej Egorov, Demetrius Matassov et al. · Virology · 1998 · 997 citations

Activation of influenza A viruses by trypsin treatment

Hans‐Dieter Klenk, R. Rott, Michaela Orlich et al. · Virology · 1975 · 838 citations

Viral Pathogenesis, Virology, Influenza Vaccine +2

Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the hemagglutinin polypeptide

Sondra G. Lazarowitz, Purnell W. Choppin · Virology · 1975 · 602 citations

Vaccination, Virus Structure, Hemagglutinin Polypeptide +6

Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein

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