Concepedia

Competitive inhibition of squalene synthetase by squalestatin 1.

Keiji Hasumi, Kiyoshi Tachikawa, Kaoru Sakai, Shigeo Murakawa, Nobuji Yoshikawa, Shigenori Kumazawa, Akira Endo

The Journal of Antibiotics · 1993 · 71 citations · 6 references

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Concepts

Abstract

3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors have received great attention as safe and effective cholesterollowering drugs1]. However, cholesterol

References

6

Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo.

A.J. Baxter, Barbara Fitzgerald, Julie L. Hutson et al. · Journal of Biological Chemistry · 1992 · 209 citations · Full text

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HMG CoA reductase inhibitors

Donald B. Hunninghake · Current Opinion in Lipidology · 1992 · 197 citations

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The squalestatings, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.

Michael J. Dawson, John E. Farthing, Peter S. Marshall et al. · The Journal of Antibiotics · 1992 · 183 citations · Full text

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Studies on the Mechanism of Squalene Biosynthesis

William W. Epstein, Hans C. Rilling · Journal of Biological Chemistry · 1970 · 97 citations · Full text

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Squalene synthetase activity in human fibroblasts: Regulation via the low density lipoprotein receptor

Jerry R. Faust, Joseph L. Goldstein, Michael S. Brown · Proceedings of the National Academy of Sciences · 1979 · 89 citations · Full text

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