Association Between Myocardial Infarction and the Mast Cells in the Adventitia of the Infarct-Related Coronary Artery

Abstract

In infarct-related coronary arteries, the number of degranulated mast cells in the adventitia backing ruptured plaques is increased. Histamine released from the degranulated mast cells may reach the media, where it may locally provoke coronary spasm and thus contribute to the onset of MI.