Tetrabutylammonium Tetra(<i>tert</i>‐Butyl Alcohol)‐Coordinated Fluoride as a Facile Fluoride Source

Abstract

F− on: The title compound TBAF(tBuOH)4 can act as a highly effective fluoride source for nucleophilic fluorination thanks to its favorable properties, such as a stable structure (in which the fluoride ion is surrounded by four bulky nonpolar protic alcohol molecules), a dehydrated state, low hygroscopicity, good solubility in organic solvents, good nucleophilicity, and low basicity.