Concepedia

Insulin-loaded PLGA/cyclodextrin large porous particles with improved aerosolization properties: In vivo deposition and hypoglycaemic activity after delivery to rat lungs

Francesca Ungaro, Concetta Giovino, Agnese Miro, Raffaella Sorrentino, Fabiana Quaglia, Maria Immacolata La Rotonda

Journal of Controlled Release · 2008 · 167 citations · 27 references

DOI

Concepts

References

27

Encyclopedia of pharmaceutical technology

Choice Reviews Online · 2003 · 1.7K citations

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Large Porous Particles for Pulmonary Drug Delivery

David A. Edwards, Justin Hanes, Giovanni Caponetti et al. · Science · 1997 · 1.2K citations

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A Theoretical Model of Erosion and Macromolecular Drug Release from Biodegrading Microspheres

Richard Batycky, Justin Hanes, Róbert Langer et al. · Journal of Pharmaceutical Sciences · 1997 · 368 citations · Full text

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Formulation and Physical Characterization of Large Porous Particles for Inhalation

Rita Vanbever, Jeffrey D. Mintzes, Jue Wang et al. · Pharmaceutical Research · 1999 · 313 citations

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Inhaled insulin1Abbreviations: DM, diabetes mellitus; AIDs, acquired immune deficiency syndrome; SC, subcutaneous; DCCT, Diabetes Control and Complications Trial; IDDM, insulin-dependent diabetes mellitus; NIDDM, non-insulin-dependent diabetes mellitus; i.v., intravenous; DDPC, di-decanoyl-alpha-phosphatidylcholine; AUC, area under the curve; INH, inhaled; Cmax, maximum serum concentration; Cmin, minimum serum concentration; Tmax, time of maximum serum concentration; NS, not significant; HbA1c, hemoglobin A1c; OA, oral agent; SD, standard deviation; MDI, metered dose inhaler; DPI, dry powder inhaler; MMAD, mass median aerodynamic diameter; CMC, critical micelle concentration; SR, sustained release; PLGA, poly lactic acid-co-glycolic acid; GI, gastrointestinal, GSD, geometric standard deviation; TLC, total lung capacity; VC, vital capacity; SMK, smokers; MW, molecular weight; MP, melting point.1

John S. Patton, Julie Bukar, Sudha Nagarajan · Advanced Drug Delivery Reviews · 1999 · 193 citations

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