Abnormal IL-1 Receptor Antagonist Production in Patients with Polymyositis and Dermatomyositis.

Abstract

Elevation of both IL-1Ra mRNA and protein in sera of patients with active-stage PM/DM suggest that higher levels of serum IL-1Ra may reflect increased IL-1Ra production in myositis, and that IL-1Ra may regulate IL-1-mediated muscle fiber damage in PM/DM.