Orthodontics and Craniofacial Research · 2002 · 19 citations · 18 references
DentistryCraniofacial BiologyOral BiologyDental Pulp BiologyEnamel BiologyOral HistologyAmeloblast DifferentiationDental AnatomyEnamel DevelopmentEnamel Developmental BiologyOral DevelopmentTooth DevelopmentDental Follicle DevelopmentNerve Growth Factor Receptor SignalingNerve Growth Factor SignalingSpatiotemporal Expression PatternsSpatiotemporal Gene ExpressionTooth Bud StageTooth Developmental BiologyTooth Morphogenesis
OBJECTIVES: The relation between nerve growth factor receptor (NGFR) in the human pre-natal tooth buds and the dental follicle was investigated. In particular, we sought to determine if there is a specific pattern of p75NGFR expression in developing human tooth buds and their surrounding tissue. SETTING AND SAMPLE POPULATION: The Department of Orthodontics at Copenhagen University, Denmark. Histological sections from 11 fetuses, aged 11-21 gestational weeks. METHOD: The sections were studied by conventional immunohistochemistry. RESULTS: Specific spatiotemporal patterns of p75NGFR reactions were observed in the tooth buds and dental follicle: Before matrix production by the ameloblasts, the entire inner enamel epithelium and the entire dental follicle display p75NGFR immunoreactivity; after matrix production is initiated, the immunoreactivity of the matrix producing cells is lost, as is that of the dental follicle adjacent to these matrix-producing cells. CONCLUSION: A unique spatiotemporal distribution of NGFR in the pre-eruptive human tooth bud was demonstrated.
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p75 and Trk: A two-receptor system
Moses V. Chao, Barbara L. Hempstead · Trends in Neurosciences · 1995 · 862 citations