Mn₊₊ BINDING BY PLASMA PROTEINS

Abstract

54 Mn 2+ added to human or rabbit plasma in vitro combines selectively with the albumin fraction. At pH 7.0, the Scatchard plot yields a curve that may be resolved for two classes of sites: one, where n 1 = 1 and K 1 = 2.4 × 10 4 , the other where n 2 = 0.5 and K 2 = 0.5 × 10 3 . Zn 2+ , Ni 2+ and Co 2+ can compete effectively for these sites.