Modulation of QT Interval by Cardiac Sympathetic Nerve Sprouting and the Mechanisms of Ventricular Arrhythmia in a Canine Model of Sudden Cardiac Death

Abstract

NGF infusion to the LSG in dogs with MI and CAVB resulted in increased QT interval and incidence of ventricular tachycardia, ventricular fibrillation, and SCD, whereas NGF infusion to the RSG shortened QT interval and reduced the incidence of ventricular tachycardia. These findings indicate that QT interval prolongation is causally related to the occurrence of ventricular arrhythmia in dogs with nerve sprouting, MI, and CAVB.