Repeated intra-hippocampal injection of beta-amyloid 25–35 induces a reproducible impairment of learning and memory: Considering caspase-3 and MAPKs activity

Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures

Madalina Stanciu, Ying Wang, Ruth Kentor et al. · Journal of Biological Chemistry · 2000 · 539 citations · Full text

Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

Qinwen Wang, Dominic M. Walsh, Michael J. Rowan et al. · Journal of Neuroscience · 2004 · 430 citations · Full text

Synaptic Transmission, Neurotransmitter, Synaptic Signaling +19

Adenosine A_2AReceptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by β-Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway

Paula M. Canas, Lisiane O. Porciúncula, Carla G. Silva et al. · Journal of Neuroscience · 2009 · 352 citations · Full text

Soluble Aβ Inhibits Specific Signal Transduction Cascades Common to the Insulin Receptor Pathway

Matthew Townsend, Tapan Mehta, Dennis J. Selkoe · Journal of Biological Chemistry · 2007 · 314 citations · Full text

Long Term Potentiation, Synaptic Transmission, Insulin Receptor +19

Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the ‘two hit’ hypothesis

Xiongwei Zhu, Rudolph J. Castellani, Atsushi Takeda et al. · Mechanisms of Ageing and Development · 2001 · 308 citations

Synaptic Plasticity, Neurodegenerative Diseases, Alzheimer's Disease +15