Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension

Bosentan Therapy for Pulmonary Arterial Hypertension

Lewis J. Rubin, David B. Badesch, Robyn J. Barst et al. · New England Journal of Medicine · 2002 · 2.7K citations · Full text

Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study

Richard N. Channick, G Simonneau, Olivier Sitbon et al. · The Lancet · 2001 · 1.5K citations

Hypertension, Pulmonary Arterial Hypertension, Pulmonary Circulation +10

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

Don K. Walker · Xenobiotica · 1999 · 401 citations

Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality

Donald J. Nichols, Gary J. Muirhead, Jane Harness · British Journal of Clinical Pharmacology · 2002 · 352 citations · Full text

Chronic Sildenafil Treatment Inhibits Monocrotaline-induced Pulmonary Hypertension in Rats

Ralph T. Schermuly, Klaus Peter Kreisselmeier, Hossein Ardeschir Ghofrani et al. · American Journal of Respiratory and Critical Care Medicine · 2003 · 259 citations