Reversal of Severe Renal Failure in Systemic Sclerosis

Abstract

Brief Reports1 November 1978Reversal of Severe Renal Failure in Systemic SclerosisMILDRED LAM, M.D., EDMOND S. RICANATI, M.D., MUHAMMAD A. KHAN, M.D., M.R.C.P., F.A.C.P., IRVING KUSHNER, M.D., F.A.C.P.MILDRED LAM, M.D.Search for more papers by this author, EDMOND S. RICANATI, M.D.Search for more papers by this author, MUHAMMAD A. KHAN, M.D., M.R.C.P., F.A.C.P.Search for more papers by this author, IRVING KUSHNER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-5-642 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRenal failure in systemic sclerosis, with or without malignant hypertension, is regarded as progressive and irreversible, leading to death within weeks to months (1, 2). We have recently seen a patient with systemic sclerosis and severe renal involvement who showed marked improvement in renal function while receiving chronic renal dialysis and antihypertensive therapy, permitting discontinuation of dialysis 1 year after onset of renal failure.A 48-year-old black woman was hospitalized in June 1976 with a 1-month history of anorexia and fatigue, and shortness of breath on...References1. CANNON P, HASSAR M, CASE D, CASARELLA W, SOMMERS S, and LEROY E: The relationship of hypertension and renal failure in scleroderma (progressive systemic sclerosis) to structural and functional abnormalities of the renal cortical circulation. Medicine (Baltimore) 53:1-46, 1974 CrossrefMedlineGoogle Scholar2. MEDSGER T and MASI A: Survival with scleroderma. II. A life-table analysis of clinical and demographic factors in 358 male U.S. veteran patients. J Chronic Dis 26:647-660, 1973 CrossrefMedlineGoogle Scholar3. KEANE W, DANIELSON B, and RAIJ L: Successful renal transplantation in progressive systemic sclerosis. Ann Intern Med 85:199-202, 1976 LinkGoogle Scholar4. MERINO G, SUTHERLAND D, KJELLSTRAND C, SIMMONS R, and NAJARIAN J: Renal transplantation for progressive systemic sclerosis with renal failure: case report and review of previous experience. Am J Surg 133:745-749, 1977 CrossrefMedlineGoogle Scholar5. CAMPBELL P and LEROY E: Pathogenesis of systemic sclerosis: a vascular hypothesis. Semin Arthritis Rheum 4:351-368, 1975 CrossrefMedlineGoogle Scholar6. LEROY E and FLEISHMANN R: The management of renal scleroderma. Experience with dialysis, nephrectomy and transplantation. Am J Med 64:974-978, 1978 CrossrefMedlineGoogle Scholar7. WASNER C, COOK C, and FRIES J: Survival with medical management after scleroderma renal crisis (abstract). Arthritis Rheum 21:600-601, 1978 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MILDRED LAM, M.D.; EDMOND S. RICANATI, M.D.; MUHAMMAD A. KHAN, M.D., M.R.C.P., F.A.C.P.; IRVING KUSHNER, M.D., F.A.C.P. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySyndromes hémolytiques et urémiques de l’adulteSyndromes hémolytiques et urémiques de l'adulteMalignant HypertensionMalignant vascular disease of the kidney: Nature of the lesions, mediators of disease progression, and the case for bilateral nephrectomyRecovery of Renal Function in Patients on Maintenance DialysisOutcome of Renal Crisis in Systemic Sclerosis: Relation to Availability of Angiotensin Converting Enzyme (ACE) InhibitorsVirginia D. Steen, MD, Joseph P. Costantino, DrPH, Alvin P. Shapiro, MD, Thomas A. Medsger Jr., MDSouthwestern Internal Medicine Conference: Clinical Features, Pathogenic Mechanisms, and New Developments in the Treatment of Systemic SclerosisAcute Renal Failure With Glomerular Thrombosis in a Patient With Chronic SclerodermaSystemic SclerosisScleroderma and scleroderma-like disordersThe cardiovascular manifestations of systemic sclerosis (scleroderma)Hypertension in Kidney DiseaseHypertension in Renal Parenchymal DiseaseVascular Nephropathies and Acute Renal Failure in AdultsReversible “end-stage” lupus nephritisRegular Dialysis Treatment (RDT)Reversal of End-Stage Kidney Failure in Two Scleroderma Patients Treated With AnticoagulationMedical Treatment of Hypertension and Renal Failure in SclerodermaExperimental modelsSCLERODERMA CRISIS: RESPONSE TO THERAPYConnective tissue diseaseMalignant hypertension: mechanisms and managementRheumatology: An Annotated Bibliography of Recent Literature References to Journal Articles and Other PapersRHEUMATOLOGY COMMITTEERenal involvement in progressive systemic sclerosis: Prolonged survival with aggressive antihypertensive managementResolution of renal failure with malignant hypertension in sclerodermaReversal of Vascular and Renal Crises of Scleroderma by Oral Angiotensin-Converting-Enzyme BlockadeProgressive Systemic Sclerosis: ManagementSome Progress with Systemic SclerosisJOHN L. ABRUZZO, M.D. 1 November 1978Volume 89, Issue 5_Part_1Page: 642-643KeywordsAntihypertensive drug therapyDyspneaFatigueHypertensionMedical dialysisRenal failureScleroderma ePublished: 1 December 2008 Issue Published: 1 November 1978 PDF downloadLoading ...