Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents

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Chemical Engineering, Cross-coupling Reaction, Engineering +14

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

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Purification and characterization of trypanothione reductase from Crithidia fasciculata, a new member of the family of disulfide-containing flavoprotein reductases

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Disulfide‐Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria

R. Heiner Schirmer, Joachim G. Müller, R. Luise Krauth‐Siegel · Angewandte Chemie International Edition in English · 1995 · 214 citations

Antiparasitic Agent, Malaria, Pharmacotherapy +20

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

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Crystal Structure, Biochemistry, Biomolecular Structure Prediction +9