American Industrial Hygiene Association Journal · 1991 · 23 citations · 0 references
Veterinary MedicinePharmacologyToxicologyNeurotoxicologyToxicodynamicsToxicologic PathologyHistopathology Of Toxic InjuryInhalation InjuryMechanisms Of Toxic InjuryPulmonary ToxicityRespiratory ToxicologyRodent ToxicologyAbnormal Gait PatternsGaitHistopathologic ExaminationHistopathology Of Inhalation InjuryHypothermiaInduced HypothermiaInhalation NeurotoxicantsInhalational Toxicity
Benzaldehyde was administered by inhalation to female and male Sprague-Dawley rats for 14 consecutive days (low level: 500 ppm; medium level: 750 ppm; high level: 1000 ppm). Effects of this chemical were investigated during and at the end of the exposure period. Throughout the experiment, significant hypothermia and a reduction of motor activity were observed in all rats exposed to benzaldehyde and were accompanied in high-level rats by a severe impairment of the central nervous system, as evidenced by abnormal gait, tremors, and a positive Straub sign. Histopathologic examination of tissues from exposed rats showed a goblet cell metaplasia that was largely confined to the respiratory epithelium lining the nasal septum in male rats. No other abnormal microscopic changes were observed. A no effect level was not observed in these studies.