Angiostatin Inhibits Coronary Angiogenesis During Impaired Production of Nitric Oxide

Abstract

Inhibition of NO synthase increased expression of angiostatin and activities of MMP-2 and MMP-9. Our findings indicate that angiostatin inhibits coronary angiogenesis during compromised NO production and may underscore the impairment of coronary angiogenesis during endothelial dysfunction.