Concepedia

Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells

Virapong Prachayasittikul, Waraporn Chan-on, Huyen Nguyen Thi Bich, Napat Songtawee, Wilasinee Suwanjang, Supaluk Prachayasittikul

Drug Design Development and Therapy · 2015 · 53 citations · 37 references

DOIFull text

Open access

Abstract

Collectively, this study reports for the first time the anticancer effects of CQ and NQ against CCA cells, and highlights new insights into the mechanism of actions of the quinoline-based compounds to disrupt FoxM1 signaling.

References

37

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

Garrett M. Morris, Ruth Huey, William Lindstrom et al. · Journal of Computational Chemistry · 2009 · 23.9K citations · Full text

The PyMOL Molecular Graphics System

Warren L. DeLano · Medical Entomology and Zoology · 2002 · 18.1K citations

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A matrix metalloproteinase expressed on the surface of invasive tumour cells

Hiroshi Sato, Takahisa Takino, Yasunori Okada et al. · Nature · 1994 · 2.6K citations

, , +11

Unified nomenclature for the winged helix/forkhead transcription factors

Klaus H. Kaestner, Walter Knöchel, Daniel E. Martínez · Genes & Development · 2000 · 1.2K citations · Full text

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Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease

Craig Ritchie, Ashley I. Bush, Andrew Mackinnon et al. · Archives of Neurology · 2003 · 974 citations