Clonidine Has Comparable Effects on Spontaneous Sympathetic Activity and Afferent Aδ– and C-Fiber-mediated Somatosympathetic Reflexes in Dogs

Abstract

Clonidine, administered intrathecally or intravenously, has a similar depressant effect on both spontaneous sympathetic outflow and afferent A delta- and C fiber-mediated somatosympathetic reflexes. When administered intrathecally it has little effect on reflexes evoked via the descending pathway by radial nerve stimulation.