Journal of Proteome Research · 2008 · 16 citations · 46 references
Life SciencesNeurosciencePharmacologyMemoryNeuropharmacologyProteomicsGabaergic SignalingHippocampal CircuitsHippocampal SystemsNeurochemical Signaling PathwaysNeuroprotectionNeurotransmissionCognitive Enhancement By Cholinergic AgentsGabaergic Role In LearningGabaergic Role In MemoryHippocampal FunctionHippocampal Memory FunctionHippocampal PhysiologyProtein Mass Spectrometry
Cognitive enhancement by the GABA (B) antagonist SGS742 has been reported and we decided to search for proteins involved. Hippocampi from OF1 mice were from SGS742- treated animals and three control groups. Proteins were extracted and run on 2DE, and spots were quantified. Significantly different protein spots were identified by two mass spectrometry principles, nano-LC-ESI-MS/MS and by nano-LC-ESI(CID/ETD)-MS/MS. Signaling, chaperone and metabolic enzyme proteins were linked to memory enhancement.
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Synaptic Strength Regulated by Palmitate Cycling on PSD-95
Alaa El-Din El-Husseini, Eric Schnell, Srikanth Dakoji et al. · Cell · 2002 · 566 citations · Full text