Stage Specific Identification of the Expression of GnRH mRNA and Localization of the GnRH Receptor in Mature Rat and Adult Human Testis

Abstract

The authors believe that the mature rat and adult human seminiferous tubular cells produce GnRH at the same specific stage of the spermatogenic cycle and that GnRH produced within seminiferous tubules, including Sertoli cells and spermatogenic cells, reacts with neighboring GnRH receptors in interstitial cells, including Leydig cells. The GnRH produced from the Sertoli cells in seminiferous tubules would react with GnRH receptors in interstitial cells as a paracrine hormone.