Baroreceptor Function Revealed by Acute Sinoaortic Denervation in Spontaneously Hypertensive Rats

Abstract

Kymographical recordings of acute effects of sinoaortic denervation on blood pressure in spontaneously hypertensive rats and normotensive Wistar rats revealed that the former showed a significantly greater pressor response than the latter after the denervation even at the age of 30-60 days, at the age corresponding to the prehypertensive stage while there was no significant difference in the pressor response between the former and the latter at the adult age. These results provide an evidence that primary defect or dysfunction of baroreceptors is not involved in the pathogenesis of spontaneous hypertension, and are rather suggestive of primary activation of vasomotor center as one of the probable causes of this hypertension.